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產品規格
售價
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BN41205R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41205R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
產品描述
| 英文名稱 | STK38 |
| 中文名稱 | 絲氨酸/蘇氨酸蛋白激酶38抗體 |
| 別 名 | NDR 1; NDR1; NDR1 protein kinase; Nuclear Dbf2 related kinase 1; Serine/threonine protein kinase 38; STK 38; STK-38; STK38_HUMAN. |
| 研究領域 | 腫瘤 細胞生物 免疫學 信號轉導 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 細胞定位 | 細胞核 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STK38:31-130/465 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38. Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2. Subunit: Homodimeric S100B binds two molecules of STK38. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Post-translational modifications: ISGylated (Probable). Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. SWISS: Q15208 Gene ID: 11329 Database links: Entrez Gene: 11329 Human Entrez Gene: 106504 Mouse Omim: 606964 Human SwissProt: Q15208 Human SwissProt: Q91VJ4 Mouse Unigene: 409578 Human Unigene: 439986 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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